Publications


Targeting latency-associated peptide promotes antitumor immunity.

Gabriely G, da Cunha AP, Rezende RM, Kenyon B, Madi A, Vandeventer T, Skillin N, Rubino S, Garo L, Mazzola MA, Kolypetri P, Lanser AJ, Moreira T, Faria AMC, Lassmann H, Kuchroo V, Murugaiyan G, Weiner HL.
Sci Immunol. 2017 May 19;2(11).

Identification and characterization of latency-associated peptide-expressing γδ T cells.

Rezende RM, da Cunha AP, Kuhn C, Rubino S, M'Hamdi H, Gabriely G, Vandeventer T, Liu S, Cialic R, Pinheiro-Rosa N, Oliveira RP, Gaublomme JT, Obholzer N, Kozubek J, Pochet N, Faria AM, Weiner HL.
Nat Commun. 2015 Dec 8;6:8726. 

In vivo anti-LAP mAb enhances IL-17/IFN-γ responses and abrogates anti-CD3-induced oral tolerance.
da Cunha AP, Wu HY, Rezende RM, Vandeventer T, Weiner HL.
Int Immunol. 2015 Feb;27(2):73-82. 

TGF-β induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction.
Oida T, Weiner HL.
PLoS One. 2010 Nov 24;5(11):e15523. 

Overexpression of TGF-ß 1 gene induces cell surface localized glucose-regulated protein 78-associated latency-associated peptide/TGF-ß.
Oida T, Weiner HL.
J Immunol. 2010 Sep 15;185(6):3529-35.

Cutting edge: human latency-associated peptide+ T cells: a novel regulatory T cell subset.
Gandhi R, Farez MF, Wang Y, Kozoriz D, Quintana FJ, Weiner HL.
J Immunol. 2010 May 1;184(9):4620-4.

Novel CD8+ Treg suppress EAE by TGF-beta- and IFN-gamma-dependent mechanisms.
Chen ML, Yan BS, Kozoriz D, Weiner HL.
Eur J Immunol. 2009 Dec;39(12):3423-35. 

Suppression of murine SLE by oral anti-CD3: inducible CD4+CD25-LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells.
Wu HY, Center EM, Tsokos GC, Weiner HL.
Lupus. 2009 Jun;18(7):586-96.

Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells.
Wu HY, Quintana FJ, Weiner HL.
J Immunol. 2008 Nov 1;181(9):6038-50.

Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis.
Chen ML, Yan BS, Bando Y, Kuchroo VK, Weiner HL.
J Immunol. 2008 Jun 1;180(11):7327-37.